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Introduces principles and methods of epidemiologic investigation of disease and other health states. Presents different types of study designs, including randomized trials, cohort and case-control studies; measurement of exposures and outcomes; risk estimation; surveillance; program evaluation; and causal inference. Discusses evaluation measures for screening programs and health interventions. Links epidemiologic inferences with the development of policy. Activities provide experience in applying epidemiologic methods, interpreting findings, and drawing inferences.